Booking and cancellation policies vary by rate type. Please check all applicable rules prior to booking to avoid possible charges. American Disabilities Act. If your accessibility needs are not met, please contact the Hotel Manager on Duty. Should you require additional information regarding accessible facilities for guests with disabilities, please call 1-800-465-4329 (U.S. and Canada) or contact the hotel directly. For the hearing impaired, TDD service is available at 1-800-238-5544 within the U.S. and Canada Welcome to the Holiday Inn Express Mechanicsburg PA. We are certain that you will relax in comfortable accommodations and enjoy our central location near the areas many businesses and most popular attractions. We are conveniently located off of Route 581 and Interstate 81. We are located 15 minutes from Carlisle and Harrisburg. Which means you can get to the Carlisle Fairgrounds or Government Offices within minutes. We are located in the middle of Chain Restaurants like Longhorn Steak House, Applebees and Olive Garden as well as Wegman's and shopping centers. Parking